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'Little justification' for record share levels
Analysts are looking ahead to the open of trading on Wall Street at 13:30 GMT.
"The rest of the day’s trading will likely be dependent on how the Dow Jones fares after the bell rings on Wall Street," said Connor Campbell from SpreadEx.
"After stagnating for most of March the Dow suffered a near 300 point drop on Tuesday, taking it to its lowest level in nearly a month; that fall has arguably been coming, with little in the way of justification – bar blind Trump optimism – to keep it so close to its record peak," he added.
US markets end lower
Wall Street stocks ended lower as a rally spurred by the Fed's decision to raise rates this week continued to lose steam.
The Dow Jones lost 0.10% to 20,914.62, the S&P 500 shed 0.13% to 2,378.25, and the Nasdaq was flat at 5,901.00.
Healthcare stocks also struggled, after a study on Amgen's cholesterol drug Repatha disappointed investors, sending its shares 6% lower.
This dragged on the S&P 500 healthcare index which fell 0.53%.
US stocks end lower
US markets broadly ended lower after poor performances from energy and healthcare stocks.
The Dow Jones index lost 0.07% to 20934.55, the S&P 500 was 0.16% lower at 2,381.38, and the Nasdaq was flat at 5,900.76.
Oil prices eased back after Wednesday's surge, sending shares of ExxonMobil, Chevron and other oil producers lower.
And healthcare stocks sagged due to mounting uncertainty over Donald Trump's policy proposals. The S&P healthcare index lost 0.9%
US markets turn negative
After opening higher US markets have turned negative thanks to a poor performance by healthcare and energy stocks.
Pharma giant Biogen lost 5% after two brokerages downgraded its stock, while the S&P 500 healthcare index slipped 1.11%.
The price of oil was down 0.8% at $48.46 a barrel as oversupply concerns lingered. Shares in oil companies suffered, with Chevron and Transocean both down.
The Dow Jones index was 0.17% lower at 20,914.50, the S&P 500 shed 0.21% to 2,380.25, and the Nasdaq was 0.05% lower at 5,897.34.